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doi: 10.1016/j.canlet.2007.10.019 200 Gonzalez-MorenoOBoqueNRedradoMMilagroFCampionJEndermannTet al

V4: Rate of uncoupled respiration (state IV), representing oxygen consumption rate after ADP has been consumed

For instance, SRT2379 was withdrawn after failing to meet efficacy expectations in a Phase I trial, highlighting unresolved issues related to tissue specificity and pathological context dependence

Research should focus on discovering reliable biomarkers that can be used in clinical settings to assess oxidative stress levels and guide therapeutic decisions